Macroporous Hydroxyapatite Scaffold Fabricated by Foam Impregnation

Abstract:

Article Preview

Submicron hydroxyapatite powder with particle size in the range of 80-250 nm was fabricated by sol-gel process in our laboratory. To make ceramic slurry with good flowability, the powder was mixed with binder and distilled water. The binder was consisted of acid magnesium and aluminum phosphates. The polyurethane foam was impregnated in the slurry, squeezed out the excess slurry and the composite porous body gained. Green body was dried in room temperature naturally and then moved to electric furnace and sintered at high temperature. The sintered scaffolds possess interconnected open pore structure and with a porosity of 70-85% and compressive strength 10-20 MPa, and was consisted of doped HA and other phosphates. The scaffolds were co-cultured with osteoblasts in vitro. SEM analyses revealed that the cells adhere to the ceramic surface, proliferate and growth properly. Experimental results showed that the scaffold possesses good biocompatibility and could be used in bone tissue engineering.

Info:

Periodical:

Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata

Pages:

565-570

Citation:

Y.S. Dong et al., "Macroporous Hydroxyapatite Scaffold Fabricated by Foam Impregnation", Key Engineering Materials, Vols. 288-289, pp. 565-570, 2005

Online since:

June 2005

Export:

Price:

$38.00

[1] D.M. Liu, T. Troczynski and W.J. Tseng: Biomaterials Vol. 22 (2001), p.1721.

[2] N.O. Engin, A.C. Tas: J. Eu. Ceram. Soc. Vol. 19 (1999), p.2569.

[3] C.E. Wilson, J.D. Bruijn and C.A. Blitterswijk et al: J. Biomed. Mater. Res. Vol. 68 (2004), p.123.

[4] H.R. Ramay, M. Zhang: Biomaterials Vol. 24 (2003), p.3293.

[5] X. Miao, Y. Hu and J. Liu et al: Mater. Lett. Vol. 58 (2004), p.397.

[6] Y.K. Jun, W.H. Kim and O.K. Kweon et al: Biomaterials Vol. 24 (2003), p.3731.

[7] M.F. Hsieh, L.H. Perng and T.S. Chin et al: Biomaterials Vol. 22 (2001), p.2601.

[8] M. Hidouri, K. Bouzouita and F. Kooli et al: Mater. Chem. Phys. Vol. 80 (2003), p.496.

[9] E. Bertoni, A. Bigi, and G. Cojazzi et al: J. Inorg. Biochem. Vol. 72 (1998), p.29. Fig. 3 SEM micrographs of osteoblasts co-cultured with HA porous scaffold after15 days, the cells and nodules (a) and the bundles of collagen fibrils (b) (a) (b).

Fetching data from Crossref.
This may take some time to load.