Biodegradable Polymer Scaffold for Tissue Engineering


Article Preview

A new method for the preparation of biodegradable porous scaffolds has been developed by using preprepared ice particulates as porogen material. A novel kind of hybrid biodegradable porous scaffold has been developed by forming collagen microsponges in the pores or interstices of a synthetic polymer sponge or mesh. A hybrid sponge of synthetic polymer, collagen and hydroxyapatite has been developed for hard tissue engineering. Bovine articular cartilage-like tissue has been engineered by culturing chondrocytes in the PLGA-collagen scaffolds.



Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata




T. Tateishi and G. P. Chen, "Biodegradable Polymer Scaffold for Tissue Engineering", Key Engineering Materials, Vols. 288-289, pp. 59-62, 2005

Online since:

June 2005




[1] T. Tateishi, G. Chen,T. Ushida, and S. Mizuno; Biodegradable Hybrid Porous Biomaterials for Tissue Engineering, Tissue Engineering And Biodegradable Equivalents(K. U. Lewandrowski, D. J. Trantolo, J. D. Gresser and D. W. Weise ed. )Marcel Dekker, (2002).

[2] T. Tateishi; Biodegradable Porous Scaffolds for Tissue Engineering, The Japan Society of Mechanical Engineers, JSME News, Vol. 13, No. 1-3(2002)6-8.

[3] T. Tateishi, G. Chen and T. Ushida:Biodegradable porous scaffold for tissue engineering, J. Artif. Organs 5(2002) 77-83.

[4] G. Chen, T. Ushida, T. Tateishi; Scaffold Design for Tissue Engineering; Macromol. Biosci. 2, (2002) 67-77.


[5] Chen G., Sato T., Ushida T., Hirochika R., Tateishi T.; Redifferentiation of dedifferentiated bovine chondrocytes when cultured in vitro in a PLGA-collagen hybrid mesh, FEBS Letters, 8 May 2003, vol. 542, no. 1, pp.95-99(5).


[6] G. Chen, T. Sato, T. Ushida, R. Hirochika, Y. Shirasaki, N. Ochiai and T. Tateishi; The use of a novel PLGA fiber/collagen composite web as a scaffold for engineering of articular cartilage tissue with adjustable thickness, J. Biomed. Mater. Res. 67A, 1170-1180(2003).


[7] Guoping Chen , Takashi Sato , Takashi Ushida , Rei Hirochika , Naoyuki Ochiai and Tetsuya Tateishi; Regeneration of cartilage tissue by combination of canine chondrocyte and a hybrid mesh scaffold, Materials Science and Engineering: C , 24-3(2004).