Poly-N-Acetyl Glucosamine as a Scaffold for Cartilage Tissue Engineering in Nude Mice
Athymic nude mice were used as an animal model to evaluate the chondrogenic effects of bovine fetal chondrocytes seeded onto a new poly-N-acetyl glucosamine sponge. Results show excellent hyaline-like cartilage formation with high glycosaminoglycan concentration after 6 weeks. At 4 weeks there is less cartilage formation and more fibrous tissue infiltrate. Although further studies are needed, these initial data support the use of poly-N-acetyl glucosamine sponge as a scaffold for cartilage tissue engineering.
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
C. M. Hill et al., "Poly-N-Acetyl Glucosamine as a Scaffold for Cartilage Tissue Engineering in Nude Mice", Key Engineering Materials, Vols. 288-289, pp. 71-74, 2005