Biomimetic Synthesis of Apatite - Polyelectrolyte Complex (Chitosan - Phosphorylated Chitosan) Hydrogel as an Osteoblast Carrier


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A novel three-dimensional scaffold of hydroxyapatite(HA)-polyelectrolyte complex (PEC) composite hydrogel was synthesized by a biomimetic method. PEC hydrogel was formed from equal volumes of 1% phosphorylated chitosan in water and 1% chitosan in 1% acetic acid solution. This PEC hydrogel was soaked in saturated Ca(OH)2 solution for 4 d and then in accelerated calcification solution (ACS) for 7 d, both at 37 oC. The PEC hydrogel was a nano-composite material with multiple levels of hierarchical porosity; hydroxyapatite (HA) crystals nucleated and grew on the fiber surfaces of the hydrogel; Rat osteoblasts were then seeded in this three-dimensional scaffold of HA-PEC composite hydrogel, the three-dimensional scaffold of HA-PEC hydrogel revealed excellent biocompatibility.



Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata




Q. L. Li et al., "Biomimetic Synthesis of Apatite - Polyelectrolyte Complex (Chitosan - Phosphorylated Chitosan) Hydrogel as an Osteoblast Carrier", Key Engineering Materials, Vols. 288-289, pp. 75-78, 2005

Online since:

June 2005




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