Paper Title:
Poly-N-Acetyl Glucosamine-SO4 for Repairing Osteochondral Defect in Rabbits
  Abstract

Repair of osteochondral defects created in rabbit femoral trochlea were studied using a water-soluble sulfated p-GlcNAc formulation, (Marine Polymer Technologies, Danvers, MA, USA). After 12 weeks of healing empty defects were compared to defects filled with sulfated p-GlcNAc sponge alone and sulfated p-GlcNAc sponge seeded with autologous chondrocytes. The chondrocyte seeded sponge provided the best healing of both cartilage and subchondral bone. The sulfated p-GlcNAc sponge alone did not provide as good healing as the chondrocyte seeded sponge, but healing was still superior to that of the empty defect. This study supports the use of p-GlcNAc sponge to augment healing of osteochondral defects in animal models.

  Info
Periodical
Key Engineering Materials (Volumes 288-289)
Edited by
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Pages
83-86
DOI
10.4028/www.scientific.net/KEM.288-289.83
Citation
Q. K. Kang, C. M. Hill, M. V. Demcheva, J. Vournakis, Y. H. An, "Poly-N-Acetyl Glucosamine-SO4 for Repairing Osteochondral Defect in Rabbits", Key Engineering Materials, Vols. 288-289, pp. 83-86, 2005
Online since
June 2005
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Price
$35.00
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