Once assessment of material failure characteristics is captured precisely in a unified way, it can be directly incorporated to the structural failure assessment under various loading environments, based on the theoretical backgrounds so called Local Approach to Fracture. The aim of this study is the development of an expert system applicable for the assessment of structural integrity throughout crack initiation and structural failure based on the Local Approach to Fracture. The generalized elasto-visco-plastic constitutive equation, which can consider the internal damage evolution behavior, was developed and employed in the 3-D FEA code in order to numerically evaluate the material and/or structural responses. Explicit information of the relationships between the mechanical properties and material constants, which are required for the mechanical constitutive and damage evolution equations for each material, was implemented in an automatic system using genetic algorithm based on an inference system. The material constants selected from genetic search and constitutive equations are used directly in the failure assessment of material and/or structures. The performance of the developed system has been evaluated for the S-N relationship assessment of several materials as well as the crack initiation assessment of various weldments in steel structures.