A Histological Evaluation of Novel Cyanoacrylate-Based β-TCP Composite in Rat Calvarial Defects

Abstract:

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In this study, the osteoconductive properties of novel cyanoacrylate-based filling materials for bone defect were evaluated. A new filling material was prepared by mixing Histoacryl® and acid-treated  -tricalcium phosphate ( -TCP). Mixing weight ratio of acid-treated  -TCP to Histoacryl® was 5:1. 12 male Spraque-Dawley rats were used in this study. The animals were divided into 4 groups. Critical-sized calvarial defects (8 mm) were created in 9 animals, and then the defects were treated with dense pellet specimen, porous cement-like specimen, and untreated defect for surgical control group. Augmentation treatments were carried out in 3 animals. Histological analysis revealed excellent ostgeoconductive properties of new filling materials. But, some of  -TCP particle in the cement-like group were encapsulated by fibrous connective tissue. For the dense pellet group and augmentation treatment group, shape and stability were better maintained during the implantation time than cement like group. These results indicate that our novel  -TCP/Histoacryl® composite have the potential to serve as filling materials for bone defects in the dental and plastic surgery.

Info:

Periodical:

Key Engineering Materials (Volumes 309-311)

Main Theme:

Edited by:

Takashi Nakamura, Kimihiro Yamashita and Masashi Neo

Pages:

1133-1136

DOI:

10.4028/www.scientific.net/KEM.309-311.1133

Citation:

S. B. Lee et al., "A Histological Evaluation of Novel Cyanoacrylate-Based β-TCP Composite in Rat Calvarial Defects ", Key Engineering Materials, Vols. 309-311, pp. 1133-1136, 2006

Online since:

May 2006

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Price:

$35.00

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