Non-Invasive Analysis of Trabecular Microstructural and Biomechanical Properties in Obese OLETF Rats


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Investigation of the bone mineral density (BMD), microstructural and mechanical properties in the Otsuka Long Evans Tokushima Fatty (OLETF) and Otsuka Long Evans Tokushima Fatty (LETO) rats were performed. The BMD and microstructural analyses were carried out using PIXI-mus and non-invasive highresolution micro-computed tomography (micro-CT) system. The mechanical properties analyses were determined by finite element analysis based on micro-images. The BMD was significantly larger in LETO rat than in OLETF rat. The microstructural and mechanical properties were deteriorated and decreased in OLETF rat. The results showed that bone strength is decreased in OLETF in spite of high body weight.



Key Engineering Materials (Volumes 321-323)

Edited by:

Seung-Seok Lee, Joon Hyun Lee, Ik Keun Park, Sung-Jin Song, Man Yong Choi




M. H. Baek et al., "Non-Invasive Analysis of Trabecular Microstructural and Biomechanical Properties in Obese OLETF Rats", Key Engineering Materials, Vols. 321-323, pp. 1129-1132, 2006

Online since:

October 2006




[1] E. Balint, P. Szabo, C. Marsholl, S. Sprague: Bone Vol. 27 (2001), pp.21-28.

[2] E. Barrett-Connor, T. Holbrook: JAMA Vol. 16 (1992), pp.3333-3337.

[3] J. Christensen, O. Svendsen: Osteoporos Int Vol. 10 (1999), pp.307-311.

[4] K. Nicodemus, A. Folsom: Diabetes Care Vol. 24 (2001), pp.1192-1197.

[5] T. Keegan, J. Kelsey, S. Sidney, C. Quesenberry: Am J Epidemiol Vol. 155 (2002), pp.926-931.

[6] A. Parfitt, M. Drezner, F. Glorieux, J. Kannis, H. Malluche, P, Meunier, S, OTT and R. Recker: J Bone Miner Res Vol. 2 (1987), pp.595-610.


[7] P. Ruegsegger, B. Koller, R. Muller: Calcified Tissue Int Vol. 58(1996), pp.24-29.

[8] D. Ulrich, B. vert Rietbergen, H. Weinans, P. Ruegsegger: J. Biomech. Vol. 31 (1998), pp.1187-1192.

[9] D. Felson, Y. Zhang, M. Hannan, J. Anderson: J Bone Miner Res. Vol. 8(1993), pp.567-573.

[10] T. Thomas, B. Burguera, L. Melton, E. Atkinson, W. O'Fallon, B. Riggs, S. Khosla: Bone Vol. 29 (2001), pp.114-120.

[11] D. Van der Voort, P. Geusens, G. Dinant: Osteoporosis Int. Vol. 12(2001), pp.630-638.

[12] H. Burger, C. De Laet, P. van Daele, A. Weel, J. Witteman, A. Hofman: Am J Epidemiol Vol. 147 (1998), pp.871-879.