A more accurate life prediction for gas turbine blade takes into account the material behavior under the complex thermo-mechanical fatigue (TMF) cycles normally encountered in turbine operation. An experimental program has been carried out to address the thermo-mechanical fatigue life of the IN738LC nickel-base superalloy. High temperature out-of-phase and in-phase TMF experiments in strain control were performed on superalloy materials. Temperature interval of 450-850 was applied to thermo-mechanical fatigue tests. The stress-strain response and the life cycle of the material were measured during the test. The mechanisms of TMF damage is discussed based on the microstructural evolution during TMF. The plastic strain energy based life pediction models were applied to the stress-strain history effect on the thermo-mechanical fatigue lives.