The hot mill spindle assembly is the important component of the hot rolling process and used for transmission of rotational power. The contact surface between end coupling and slipper metal have high stress concentration due to operation interference. The life cycles of slipper metal are reduced by the contact surface damage. In this study, the structural analysis and kinematics simulation are performed by applying the various driving angle and dynamic boundary condition of the mill spindle assembly. This study aims to minimize the contact damage which might happen in the production process.