Preparation of Hydroxyapatite-Alginate Gels as a Carrier for Controlled Release of Paclitaxel
Hydroxyapatite (HAp)-alginate gels were developed as drug delivery carriers of the anti-cancer drug, water-insoluble paclitaxel (Taxol). The spray-drying technique was employed for loading the paclitaxel into spherical HAp microparticles with 1 to 20 μm in diameter. The microparticles loaded with 2.4 or 7.3wt% of paclitaxel were then mixed with sodium alginate, which was followed by Ca2+-mediated gelation. The compressive strength of the HAp-alginate gels and the release of paclitaxel from the gels in a medium were investigated in vitro. The alginate matrix was effective for the achievement of controlled release of anti-cancer drugs.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
T. Yoshioka et al., "Preparation of Hydroxyapatite-Alginate Gels as a Carrier for Controlled Release of Paclitaxel", Key Engineering Materials, Vols. 330-332, pp. 1053-1056, 2007