Preparation of Hydroxyapatite-Alginate Gels as a Carrier for Controlled Release of Paclitaxel

Abstract:

Article Preview

Hydroxyapatite (HAp)-alginate gels were developed as drug delivery carriers of the anti-cancer drug, water-insoluble paclitaxel (Taxol). The spray-drying technique was employed for loading the paclitaxel into spherical HAp microparticles with 1 to 20 μm in diameter. The microparticles loaded with 2.4 or 7.3wt% of paclitaxel were then mixed with sodium alginate, which was followed by Ca2+-mediated gelation. The compressive strength of the HAp-alginate gels and the release of paclitaxel from the gels in a medium were investigated in vitro. The alginate matrix was effective for the achievement of controlled release of anti-cancer drugs.

Info:

Periodical:

Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu

Pages:

1053-1056

DOI:

10.4028/www.scientific.net/KEM.330-332.1053

Citation:

T. Yoshioka et al., "Preparation of Hydroxyapatite-Alginate Gels as a Carrier for Controlled Release of Paclitaxel", Key Engineering Materials, Vols. 330-332, pp. 1053-1056, 2007

Online since:

February 2007

Export:

Price:

$35.00

[1] M. Itokazu, T. Sugiyama, T. Ohno, E. Wada and Y. Katagiri: J Biomed Mater Res Vol. 39(1998), p.536.

[2] T. Matsumoto, M. Okazaki, M. Inoue, S. Yamaguchi, T. Kusunose, T. Toyonaga, Y. Hamada and J. Takahashi: Biomaterials Vol. 25(2004), p.3807.

DOI: 10.1016/j.biomaterials.2003.10.081

[3] Y. Mizushima, T. Ikoma, J. Tanaka, K. Hoshi, T. Ishihara, Y. Ogawa and A. Ueno: J Controlled Release Vol. 110(2006), p.260.

[4] W. Paul and C. P. Sharma: J Mater Sci Lett Vol. 16(1997), p. (2050).

[5] M. Sivakumar and K. Panduranga Rao: J Biomed Mater Res Vol. 65A(2003), p.222.

[6] E. Krylova, A. Ivanov, V. Orlovski, G. EL-Registan and S. Barinov: J Mater Sci: Mater Med Vol. 13(2002), p.87.

DOI: 10.1023/a:1013603106502

[7] H. H. Pham, P. Luo, F. Genin and A. K. Dash: AAPS Pharm Sci Tech Vol. 3(2002), E1.

[8] A. Barroug and M. J. Glimcher: J Orthop Res Vol. 20(2002).

In order to see related information, you need to Login.