Ectopic Osteogenesis of Bone Marrow Stromal Cells Loading in Hydroxyapatite/ β-Tricalcium Phosphate


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This study was to determine the ectopic osteogenic ability of BMSCs in combination with a scaffolding material comprising hydroxyapatite and β-tricalcium phosphate matrix (HA/β-TCP). BMSCs were obtained from the SD rats and induced to osteogenesis. Then these induced cells were seeded into HA/β-TCP and the constructs were auto-implanted subcutaneously for up to 12 weeks. Histological analysis, immunostaing, RT-PCR and transmission electron microscopy of the retrieved specimens at various intervals showed obvious trends of ectopic bone formation with obvious alteration of cellular phenotype.



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




Y. F. Lin et al., "Ectopic Osteogenesis of Bone Marrow Stromal Cells Loading in Hydroxyapatite/ β-Tricalcium Phosphate", Key Engineering Materials, Vols. 330-332, pp. 1109-1112, 2007

Online since:

February 2007




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