Preparation of Poly(L-lactic Acid) Hybrid Membrane with Silicon-Ion-Releasing Ability


Article Preview

A novel poly(lactic acid) (PLA)/calcium carbonates hybrid membrane containing siloxane was prepared using aminopropyltriethoxysilane (APTES) for biodegradable bone guided regeneration. The PLLA in the membrane was an amorphous phase. By heating the membrane at 100 °C for 1 h, the PLLA in the membrane crystallized. Numerous pores of 0.5-1 ,m in diameter were newly formed at the surface. After soaking the membranes before and after heat-treatment in simulated body fluid, the amount of silicon species in SBF released from the membrane after heat-treatment was higher than that before heat-treatment. A test of osteoblast-like cellular proliferation on the membrane showed the membrane after heat-treatment has much higher cell-proliferation ability than that before heat-treatment.



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




H. Maeda et al., "Preparation of Poly(L-lactic Acid) Hybrid Membrane with Silicon-Ion-Releasing Ability", Key Engineering Materials, Vols. 330-332, pp. 1305-1308, 2007

Online since:

February 2007




[1] I.D. Xynos, A.J. Edgar, L.D.K. Buttery, L.L. Hench and J.M. Polak: Biochem. Biophys. Res. Comm. Vol. 276 (2000), p.461.

[2] H. Maeda, T. Kasuga and L.L. Hench: Biomater. Vol. 27 (2006), p.1216.

[3] L.H.H.O. Damink, P.J. Dijkstra, M.L.A. Luyn, P.B. Wachem, P. Nieuwenhuis and J. Feijen: Biomater. Vol. 17 (1996), p.765.


[4] T. Kasuga, H. Maeda, K. Kato, M. Nogami, K. Hata and M. Ueda: Biomater. Vol. 24 (2003), p.3247.

[5] A. Park and L.G. Cima: J. Biomed. Mater. Res. Vol. 31 (1996), p.17.

[6] L. Montanaro, C.R. Arciola, D. Campoccia and M. Cervellati M: Biomater. Vol. 23 (2002), p.3651.

[7] D.D. Deligianni, N.D. Katsala, P.G. Koutsoukos and Y.F. Missirlis: Biomater. Vol. 22 (2001), p.87.