In Vitro and In Vivo Bactericidal Effect of Sol-Gel/Antibiotic Thin Films on Fixation Devices


Article Preview

Beneficial properties of room temperature processed silica sol-gels as resorbable and biocompatible materials for the controlled release of drugs and macromolecules have been described before. Recently, it was shown that a thin sol-gel film can be used for the controlled delivery of antibiotics such as vancomycin. It was also demonstrated that the release and degradation properties of the sol-gel films can be tailored via processing parameters. In this work, we evaluated the in vitro and in vivo bactericidal effects of vancomycin-containing thin sol-gel films applied on Ti-alloy intramedullary nails. Both the in vitro and the in vivo results demonstrate a pronounced bactericidal effect of the sol-gel/antibiotic films. This study suggests that thin antibiotic-containing sol-gel film holds great promise for the prevention and treatment of bone infections.



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




S. Radin et al., "In Vitro and In Vivo Bactericidal Effect of Sol-Gel/Antibiotic Thin Films on Fixation Devices", Key Engineering Materials, Vols. 330-332, pp. 1323-1326, 2007

Online since:

February 2007




[1] S. Radin and P. Ducheyne: Nanostructural control of implantable xerogels for the controlled release of biomolecules in R. Reis, S. Weiner, Learning from Nature How to Design New Implantable Biomaterials, Kluwer, The Netherlands, 2004, 59.


[2] H. Bottcher, P. Slovik, W. Suss: J. Sol-Gel Sci Tech Vol 13 (1998), p.277.

[3] M Ahola, P. Kortesuo, I. Kangasniemi, J. Kiesvaara, A. Yli-Urpo: Int. J. Pharm. Vol. 195 (2000), p.219.


[4] S. Radin, P. Ducheyne, T. Kamplain, B.H. Tan: J. Biomed. Mater. Res. Vol. 57 (2001), p.321.

[5] S. Radin, J. Parvizi, P. Ducheyne: Key Engineering Materials, Vols. 309-311 (2006), p.759.