In Vitro and In Vivo Bactericidal Effect of Sol-Gel/Antibiotic Thin Films on Fixation Devices
Beneficial properties of room temperature processed silica sol-gels as resorbable and biocompatible materials for the controlled release of drugs and macromolecules have been described before. Recently, it was shown that a thin sol-gel film can be used for the controlled delivery of antibiotics such as vancomycin. It was also demonstrated that the release and degradation properties of the sol-gel films can be tailored via processing parameters. In this work, we evaluated the in vitro and in vivo bactericidal effects of vancomycin-containing thin sol-gel films applied on Ti-alloy intramedullary nails. Both the in vitro and the in vivo results demonstrate a pronounced bactericidal effect of the sol-gel/antibiotic films. This study suggests that thin antibiotic-containing sol-gel film holds great promise for the prevention and treatment of bone infections.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
S. Radin et al., "In Vitro and In Vivo Bactericidal Effect of Sol-Gel/Antibiotic Thin Films on Fixation Devices", Key Engineering Materials, Vols. 330-332, pp. 1323-1326, 2007