Development of Biocompatible Glues for Minimum Invasive Therapy


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A biocompatible glue consisting of human serum albumin (HSA) and citric acid derivative (CAD), named CAD-A glue was developed. CAD was successfully synthesized by the reaction between citric acid and N-hydroxysuccinimide in the presence of 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride. When the CAD-A glue was applied to the collagenbased casings, it took 7 min to obtain half of maximum bonding strength (760 g/cm2). The bonding strength of this glue to collagen-based casings increased with increasing of HSA concentration.The bonding strength of CAD-A glue increased with increasing CAD concentration up to 200 mM, and then decreased with increasing CAD concentration under the fixed HSA concentration (50 w/w%). The CAD-A glue showed excellent wound closure ability rather than fibrin glue when applied to the mouse skin. These results suggested that this developed glue had both tissue compatibility and bonding strength for use in clinical field.



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




T. Taguchi et al., "Development of Biocompatible Glues for Minimum Invasive Therapy", Key Engineering Materials, Vols. 330-332, pp. 1339-1342, 2007

Online since:

February 2007




[1] L. Morgenstern, Am. Surg. Vol. 31, 709 (1965).

[2] J. V. Quinn, Glues in Wound Care, B. C. Becker Inc. Hamilton, London (1998), p.33.

[3] P. B. Vanwachem, M. J. A. Vanluym, L. H. M. O. Damink, P. J. Dijkstra, J. Feijen and P. Nieuwenhuisp, J. Biomed. Mater. Res., vol. 28: p.353 (1994).

[4] D. F. Thompson and G. D. Thompson, Drug Intel. Clin. Pham., vol. 22: p.946 (1988).

[5] H. W. Sung, D. M. Huang, W. H. Chang, R. N. Huang and J. C. Hsu, J. Biomed. Mater. Res., vol. 46: p.520 (1999).

[6] T. Sekine, T. Nakamura, Y. Shimizu, H. Ueda, K. Matsumoto, Y. Takimoto, T. Kiyotani, J. Biomed. Mater. Res., vol. 54: p.305 (2001).

[7] H. W. Sung, R. N. Huang, L. L. H. Huang and C. C. Tsai, J. Biomater. Sci. Polym. Ed., vol. 10: p.63 (1999).

[8] H. Iwata, S. Matsuda, K. Mitsuhashi, E. Itho and Y. Ikada, Biomaterials, vol. 19, p.1869 (1998).

[9] T. Taguchi, H. Saito, Y. Uchida, M. Sakane, H. Kobayashi, K. Kataoka and J. Tanaka, Mater. Sci. Eng. C, 24, 775 (2004).

[10] T. Taguchi, H. Saito, M. Iwasashi, M. Sakane, S. Kakinoki and J. Tanaka, J. Nanosci. Nanotechnol., in press.