Novel Local Treatment with Paclitaxel-Loaded Hydroxyapatite-Alginate Gels for Spinal Bone Metastases


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The extent of osseous involvement, particularly spinal cord compression, is directly correlated with patient survival. To treat metastatic spine cancer, we have developed novel paclitaxel-loaded hydroxyapatite-alginate gels. In this study, an intraosseous spinal cancer model in rats was used to investigate the efficacy of local treatment. Ten rats were randomized into two groups, a local treatment group and a control group. Disease-free time and survival rate in the local treatment group were significantly longer in this model. (p<0.05)



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




T. Abe et al., "Novel Local Treatment with Paclitaxel-Loaded Hydroxyapatite-Alginate Gels for Spinal Bone Metastases", Key Engineering Materials, Vols. 330-332, pp. 1343-1346, 2007

Online since:

February 2007




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