Effect of Apatite Nanoparticles on Remineralization of the Demineralized Human Dentin


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The aim of this study was to evaluate the remineralizing potential of demineralized human dentin treated with Y/HA nanoparticles (doping Y with 5mol %) and HA nanoparticles suspension and whether dentin could be remineralized by HA. Human crown dentin was demineralized with EDTA for 4 hours, and then subjected to remineralization condition. The ability of these matrices to remineralize was determined by SEM, AFM and calcium levels in the remineralized tissue were measured by atomic energy spectrum analysis. The results showed that Y/HA and HA nanoparticles remineralized the demineralized dentin surface; these demineralized matrices treated with Y/HA nanoparticles remineralized to a greater extent than those treated HA nanoparticles. The differences in both the quality and quantity, as defined by Yttrium iones leading to changes in characterization of the apatite crystals might be important in effecting the ability of this tissue to remineralize. This work suggested that apatite nanoparticles caused remineralization of dentin and the yttrium ions substituted in the apatite structure might enhance their remineralization potential.



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




Z. Tan et al., "Effect of Apatite Nanoparticles on Remineralization of the Demineralized Human Dentin", Key Engineering Materials, Vols. 330-332, pp. 1381-1384, 2007

Online since:

February 2007




[1] ten Cate JM, J Dent Res. Vol. 80(2001) p.1407.

[2] Maksimovskii IuM and Zemskova MI. Stomatologiia (Mosk). Vol. 73(1994)p.14.

[3] Klont B and ten Cate JM. Caries Res.; 25 (1991) p.39.

[4] K Kawasaki, J Ruben, I Stokroo, et al. J Arends; The remineralization of EDTA-treated human dentine Caries Research 1999; 33(4)p.275.

DOI: https://doi.org/10.1159/000016529

[5] Lussi A, Linde A: Mineral induction in vivo by dentine proteins. Caries Res; 27(1993) p.241.

DOI: https://doi.org/10.1159/000261544

[6] Saito T, Yamauchi M, Crenshaw MA. Apatite induction by insoluble dentin collagen. J Bone Miner Res Vol. 1998 Feb; 13(2) p.265.

DOI: https://doi.org/10.1359/jbmr.1998.13.2.265

[7] Clarkson BH, Chang SR, Holland GR. Caries Res Vol. 1998; 32(5) p.357.