Biocompatibility of Nano-TiO2/HA Bioceramic Coating for Nerve Regeneration around Dental Implants


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Sensory perception thresholds of implants were much higher than those of natural teeth. The purpose of this study was to evaluate the biocompatibility of TiO2/HA-biocoated dental implants for nerve regeneration using cultured Schwann cells. The nano-TiO2/HA composite bioceramic coating was developed on the surfaces of commercially pure titanium discs by sol-gel route, and characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Using smooth titanium discs as a control, Schwann cell responses to the coating were evaluated by SEM, MTT assay, total protein content and leakage of cytosolic lactate dehydrogenase (LDH) activity. In addition, the amount of brain-derived neurotrophic factor (BDNF) secreted by Schwann cells was measured by Enzyme-Linked Immunosorbent Assay (ELISA). It was observed that the coating had fine crystallites and homogeneous micropores in the diameter of 5-10 um. The cell morphology, proliferation and function were unaffected. The results indicate that the TiO2/HA bioceramic coating developed on the surface of pure titanium by sol-gel route had good biocompatibility with Schwann cells for nerve regeneration around dental implants.



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




Q. Yuan et al., "Biocompatibility of Nano-TiO2/HA Bioceramic Coating for Nerve Regeneration around Dental Implants", Key Engineering Materials, Vols. 330-332, pp. 1393-1396, 2007

Online since:

February 2007




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