Biocompatibility of Nano-TiO2/HA Bioceramic Coating for Nerve Regeneration around Dental Implants

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Sensory perception thresholds of implants were much higher than those of natural teeth. The purpose of this study was to evaluate the biocompatibility of TiO2/HA-biocoated dental implants for nerve regeneration using cultured Schwann cells. The nano-TiO2/HA composite bioceramic coating was developed on the surfaces of commercially pure titanium discs by sol-gel route, and characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Using smooth titanium discs as a control, Schwann cell responses to the coating were evaluated by SEM, MTT assay, total protein content and leakage of cytosolic lactate dehydrogenase (LDH) activity. In addition, the amount of brain-derived neurotrophic factor (BDNF) secreted by Schwann cells was measured by Enzyme-Linked Immunosorbent Assay (ELISA). It was observed that the coating had fine crystallites and homogeneous micropores in the diameter of 5-10 um. The cell morphology, proliferation and function were unaffected. The results indicate that the TiO2/HA bioceramic coating developed on the surface of pure titanium by sol-gel route had good biocompatibility with Schwann cells for nerve regeneration around dental implants.

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Periodical:

Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu

Pages:

1393-1396

Citation:

Q. Yuan et al., "Biocompatibility of Nano-TiO2/HA Bioceramic Coating for Nerve Regeneration around Dental Implants", Key Engineering Materials, Vols. 330-332, pp. 1393-1396, 2007

Online since:

February 2007

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$38.00

[1] T. Albrektsson, and M Jacobsson: J Prosthet. Dent. Vol. 57 (1987), p.597.

[2] H.W. Kim, Y.H. Koh, L.H. Li: Biomaterials Vol. 25 (2004), p.2533.

[3] R. Ulrich, L. Muhlbradt, H. Mohlmann: Int J Oral Maxillofac Implants Vol. 8 (1993), p.173.

[4] S. Weiner, D. Sirois, D. Ehrenberg: Int J Oral Maxillofac Implants Vol. 19 (2005), p.44.

[5] S. Wada, T. Kojo, YH Wang: Clin. Oral Impl. Res. Vol. 12 (2001), p.219.

[6] Z.L. Shen, A. Berger, R. Hierner. Microsurgery Vol. 21(2001), p.6.

[7] S. Wakisaka, and Y. Atsumi: Microsc. Res. Tech. Vol. 60 (2003), p.516.

[8] 8 S. Itoh, I. Yamaguchi, M. Suzuki: Brain Research Vol. 993 (2003), p.111.

[9] 9 M.C. Cehreli, M.A. Onur, S. Sahin: Clin. Oral Impl. Res. Vol. 14 (2002), p.269.