Dialysis Preparation of Zinc-Substituted Nano-Hydroxyapatite and Its Characterization
Nano-sized zinc-substituted hydroxyapatite (nano-ZnHA) has stimulatory effect on bone formation and inhibitory effect on osteoclastic bone resorption in vivo. Nano-ZnHA with serial zinc fractions (0, 2, 5, 10 mol%) were synthesized by an improved precipitation method based on dialysis process. Transmission electron microscopy observation indicated that the increase of Zn fraction led to smaller crystallite. X-ray diffraction of the products revealed that some typical characteristic peaks of HA displayed when the Zn fraction was below 10%. Fourier transform infrared spectroscopy showed that the bending peaks of the group-OH in HA became wider with the increase of Zn fraction and it disappeared at 10 mol%. The current work demonstrated that zinc could substitute for calcium into hydroxyapatite in the limited range of composition by using dialysis process.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
S. M. Zhang et al., "Dialysis Preparation of Zinc-Substituted Nano-Hydroxyapatite and Its Characterization", Key Engineering Materials, Vols. 330-332, pp. 219-222, 2007