Synthesis of Albumin/DCP Nano-Composite Particles


Article Preview

Highly disgregated dicalcium phosphate anhydrate (DCP) nanoparticles 240-367 nm in diameter were synthesized by a reaction between calcium carbonate and phosphoric acid. When the DCP nanoparticles were immersed in a supersaturated calcium phosphate solution containing bovine serum albumin (BSA) and ethanol, BSA/DCP nano-composite particles were synthesized through the coprecipitation of BSA on the DCP nanoparticles. BSA was firmly immobilized on the BSA/DCP nano-composite particles. The results of this study suggest that DCP nanoparticles appear to be useful as a drug delivery vehicle.



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




H. Ohsawa et al., "Synthesis of Albumin/DCP Nano-Composite Particles", Key Engineering Materials, Vols. 330-332, pp. 239-242, 2007

Online since:

February 2007




[1] T. Matsumoto, M. Okazaki, M. Inoue, S. Yamaguchi, T. Kusunose, T. Toyonaga, Y. Hamada, J. Takahashi: Biomaterials, Vol. 25(2004), p.3807.


[2] W. Paul, J. Nesamony, C. P. Sharma: J. Biomed. Mater. Res. Vol. 61(2002), p.660.

[3] K. Inoue, K. Sassa, Y. Yokogawa, Y. Sakka, M. Okido and S. Asai: Bioceramics, Vol. 15(2002), p.513.

[4] Fujii O, Ito A, Otsuka R, Aoki H, Akao M: Gypsum and Lime 219, (1989) p.68 (Japanese).

[5] Y. Sogo, A. Ito, K. Fukasawa et al: Curr Appl Phys Vol. 5(2005), p.526.

[6] M. Uchida, A. Oyane et al.: Adv. Mater., Vol. 16(2004), p.1071.

[7] A. Oyane, M. Uchida and A. Ito: J. Biomed. Mater. Res., Vol. 72A(2005).