Synthesis of Albumin/DCP Nano-Composite Particles
Highly disgregated dicalcium phosphate anhydrate (DCP) nanoparticles 240-367 nm in diameter were synthesized by a reaction between calcium carbonate and phosphoric acid. When the DCP nanoparticles were immersed in a supersaturated calcium phosphate solution containing bovine serum albumin (BSA) and ethanol, BSA/DCP nano-composite particles were synthesized through the coprecipitation of BSA on the DCP nanoparticles. BSA was firmly immobilized on the BSA/DCP nano-composite particles. The results of this study suggest that DCP nanoparticles appear to be useful as a drug delivery vehicle.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
H. Ohsawa et al., "Synthesis of Albumin/DCP Nano-Composite Particles", Key Engineering Materials, Vols. 330-332, pp. 239-242, 2007