Comparison of Biomineralization on Calcium Phosphate Implants in Rabbit and Dog Models
Porous alpha- tricalcium phosphate (α-TCP) was implanted in rabbit and dog models to investigate its induction of calcium phosphate (Ca-P) formation. The morphology and structure of the formed Ca-Ps were examined using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), respectively. The results showed an animal-dependent behavior of in vivo Ca-P formation. There were flake-like octacalcium phosphate (OCP) precipitates in the rabbit but rod-like hydroxyapatite (HA) precipitates in the dog model. In addition, high-resolution TEM (HRTEM) image revealed that there was OCP structure in certain portions of the rod-like HA precipitates in the dog model. And the orientation relation of OCP/HA was deduced as OCP (010)//HA (0 10) and OCP (001)//HA (00 1) . This implied that the in vivo HA was formed via OCP precursor phase.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
R. L. Xin et al., "Comparison of Biomineralization on Calcium Phosphate Implants in Rabbit and Dog Models", Key Engineering Materials, Vols. 330-332, pp. 27-30, 2007