Synthesis and Characterization of Yttrium/Hydroxyapatite Nanoparticles


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The aim of this study was to synthesize yttrium/hydroxyapatite(Y/HA) nanoparticles and submit to a structural, chemical and biological characterization. The microstructure, shape and size, concentration of yttrium released in water were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM) and Inductively coupled plasma (ICP). The biological actions were evaluated by the cell cultivation method and oral bacterial colony counting method. The results showed that yttrium can be incorporated into the hydroxyapatite structure. Sizes of the nanocrystals were less than 100nm. The shape was needle-like. The human periodontal fibroblast growth was accelerated and oral bacterial growth was lightly restricted. The data indicate that the hydrothermally synthetized approach can be successfully used to prepare yttrium/hydroxyapatite nanocrystals with crystallinity, crystal dimensions, structure and stability close to those characteristic of biological apatite and with better biological activity, bacteriostasis.



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




Y. Liu et al., "Synthesis and Characterization of Yttrium/Hydroxyapatite Nanoparticles", Key Engineering Materials, Vols. 330-332, pp. 295-298, 2007

Online since:

February 2007




[1] Y.B. Li: J Mater Sci.: Mater in Medicine Vol. 5 (1994), p.326.

[2] S.I. Stupp and G.W. Ciegler: J Biomed Mater Res. Vol. 26 (1992), p.169.

[3] W. Kong and X.Y. Zhang: Study of Trace Elements and Health. Vol. 17(2000), p.67.

[4] Q. Qiu, J.K. Zhang and M. Zhang: J Biomed En. Vol. 15(1998), p.12.

[5] H. Aoki: Medical Applications of Hydroxyapatite ( Ishiyaku EuroAmerica, Inc. Tokyo, St. Louis 1995).

[6] Y.X. Wang: X-ray and X-ray diffraction (Higher education publishing company, Beijing 1986).

[7] A.C. Mo, H.K. Wu, Z.Q. Chen and Y.B. Li: J Oral Sci Res. Vol. 19(2003), p.454.

[8] R.R. Nie, A.C. Mo, H.K. Wu, Z.Q. Chen and Y. B Li: Journal of Wuhan University of Technology-Mater Sci Ed. Vol. 20(2005), p.102.

[9] R.N. Correia, M.C. Magalhaes and PAAP. Fmarques: J Mat Sci: Mat in Med. Vol. 7(1996), p.501.

[10] Sadae, Kumazawah and Murakamiy: Chem Eng Comm. Vol. 103(1991), p.57.

[11] W.L. Suchanek, P. Shuk, K. Byrappa, R.E. Riman, K.S. TenHuisen and V.F. Janas: Biomaterials Vol. 23 (2002), p.699.


[12] S. Nakamura, T. Isobe and M. Senna: J. Nanopartical Res. Vol. 3(2001), p.57.

[13] C. Ergun, T.J. Webster, R. Bizios and R.H. Doremus: J Biomed Mater Res. Vol. 59 (2002), p.305.

[14] T.J. Webster, C. Ergun, R.H. Doremus, R.W. Siegel and R. Bizios: J Biomed Mater Res. Vol. 59 (2002), p.312.