Preparation and Characterization of the Microspheres Comprised of Atelocollagen and BCP
In order to develop a bone-filling material with osteoinductive potential, a composite micorspheres of collagen molecules and biphasic calcium phosphate (BCP) was prepared by utilizing emulsion polymerization and the intrinsic self-assembly of collagen. The prepared microspheres were analyzed by granularity test, scanning electron microscopy (SEM), infrared spectra (IR) and enzymatic digestion experiment. The results showed that the collagen matrix of fibrils was reconstituted in the droplets, and the native triple-helix structure of collagen was still maintained. The study provides an effective way to prepare microspheres of collagen and BCP composite.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Q. R. Wei et al., "Preparation and Characterization of the Microspheres Comprised of Atelocollagen and BCP", Key Engineering Materials, Vols. 330-332, pp. 423-426, 2007