Bioactive Hydroxyapatite/ Polyvinyl Alcohol Composite for Repair and Regeneration of Articular Cartilage


Article Preview

In this work, a new kind of bioactive PVA/HA hydrogels use as artificial cartilage were prepared by in situ sol-gel synthesis method. Simulated experiments were performed to evaluate and compare the bioactive ability and properties of the hydrogels in simulated body solution. PVA/HA Cartilage implants were developed and used to repair articular cartilage defect in rabbit knee. The macroscopic and histological observation of animal experiments displayed that the implanted hydrogels combined tightly to ambient tissues, and some bone-like tissue grew into the bottom of the implants from the base-bone to form more deep-set binding.



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




Y. D. Zheng et al., "Bioactive Hydroxyapatite/ Polyvinyl Alcohol Composite for Repair and Regeneration of Articular Cartilage", Key Engineering Materials, Vols. 330-332, pp. 475-478, 2007

Online since:

February 2007




[1] Mayne R., Arthitis Rheum., Vol. 32(1) (1989), p.241.

[2] Nordin M., Frankel VH., Guo BF,Clinical Orthopaedics Biomechanics ,Shanghai far east Publishing Company, 57-60(1993).

[3] Kobayashi M,Toguchid J, Oka M, Biomaterials, 24(2003), p.639.

[4] Darwis D, Stasica P, Razzak MT, Rosiak JM, Radiation Physics and Chemistry, 63(2002), p.539.


[5] Scortkroff S., Barone L., Hsu H P, Wrenn T, Gagne T, Chi T, Breinan, H, Biomaterials, Vol. 17(1996), p.147.

[6] Zheng YD, Wang YJ , Liu Q, Zhu XL, Wu G, China Patent ZL02134218. 0(2005).

[7] Hench LL. J Am Ceram Soc, 74(1991), p.1487.

[8] Kokubo T. J Ceram Soc Jpn, 99(1991), p.965.

[9] Zheng YD, Wang YJ, Liu Q, Chen XF, Wu G, Chemical Journal of Chinese University, 26(2005), p.1735.

[10] Pereira MM, Clark AE, Hench LL, J. Biomed. Mat. Res., 28(1994), p.693. a: 4weeks b: 12weeks Fig. 4 Histological states observation of cartilage cut repaired by PVA/HA hydrogels.