A Study of Bone-Like Apatite Formation on β-TCP/PLLA Scaffold in Static and Dynamic Simulated Body Fluid

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The ability of apatite to form on the surface of biomaterials in simulated body fluid (SBF) has been widely used to predict the bone-bonding ability of bioceramic and bioceramic/polymer composites in vivo. Porous β-tricalcium phosphate/poly(L-lactic acid) (β-TCP/PLLA) composite scaffold was synthesized by new method. The ability of inducing calcium phosphate (Ca-P) formation was compared in static simulated body fluid(sSBF) and dynamic simulated body fluid (dSBF). The Ca-P morphology and crystal structures were identified using SEM, X-ray diffraction and Fourier transform infrared (FT-IR) spectroscopy. The results showed that the typical features of bone-like apatite formation on the surface and the inner pore wall of β-TCP/PLLA. Ca-P formation on scaffold surfaces in dSBF occurred slower than in sSBF and was more difficult with increasing flow rate of dSBF. The ability of apatite to form on β-TCP/PLLA was enhanced by effect of each other that has different degradable mechanism. Porous β-TCP/PLLA composite scaffold indicates good ability of Ca-P formation in vitro.

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Periodical:

Key Engineering Materials (Volumes 330-332)

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Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu

Pages:

483-486

Citation:

Y. Q. Kang et al., "A Study of Bone-Like Apatite Formation on β-TCP/PLLA Scaffold in Static and Dynamic Simulated Body Fluid", Key Engineering Materials, Vols. 330-332, pp. 483-486, 2007

Online since:

February 2007

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$38.00

[1] Kokubo T: Biomaterials Vol. 12 (1991), p.155.

[2] Kim HM, Miyaji F, Kokubl T and Nakamura T: J Biomed Mater Res Vol. 32 (1996), p.409.

[3] Legeros RZ, Lin S and Rohanizadeh R: J Mater Sci Mater Med Vol. 14 (2003), p.201.

[4] Ohtsuki C, Kushitani H and Kokubo T: J Biomed Mater Res Vol. 25 (1991), p.1363.

[5] Ohtsuki C, Kokubo T, Neo M and Kotani S: Phos Res Bull Vol. 1 (1991), p.191.

[6] Renlong Xin, Yang Leng, Jiyong Chen and Qiyi Zhang: Biomaterials Vol. 26 (2005), p.6477.

DOI: https://doi.org/10.1016/j.biomaterials.2005.04.028

[7] Kai Zhang, Yunbing Wang and Marc A. Hillmyer: Biomaterials Vol. 25 (2004), p.2489.

[8] Tadashi Kokubo, Hiroaki Takadama: Biomaterials Vol. 27 (2006), p.2907.

[9] Xiong Lu, Yang Leng: Key Eng. Mater Vol. 192-195 (2001), p.47.

[10] V. Andre-Frei, B. Chevallay and I. Orly: Calcif. Tissue Int., Vol. 66 (2000), p.204. Fig. 4 FTIR spectra displaying carbonate peaks (■) and hydroxyl stretch (●) in dSBF.