A Novel Way of Dispersing Fine Ceramic Particles in PLGA Matrix


Article Preview

α-tricalcium phosphate (α-TCP) was prepared by a wet precipitation reaction between calcium hydroxide and orthophosphoric acid solutions. The as-synthesised powder was then characterised using a Scanning Electron Microscope (SEM) equipped with Energy Dispersive Spectroscope (EDS), X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscope (FTIR). Analyses revealed that a phase-pure powder with a Ca/P ratio of 1.5 was produced. In addition, nanosized α-TCP particles of diameter ~ 70 nm were agglomerated to form larger particles of 10μm in diameter. It was found that by the combination of attritor milling and solution evaporation, the agglomerates of α-TCP nanoparticles could be broken down, and distributed evenly within the poly(D,L-lactic-co-glycolic acid) (PLGA) matrix. Thus, a α-TCP/PLGA nanocomposite was successfully produced by a modified solution evaporation method at room temperature followed by hot pressing at 150 °C. The achievable ceramic loading was approximately 38 wt.%, which was confirmed by thermal gravimetric analysis (TGA).



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




Z. Yang et al., "A Novel Way of Dispersing Fine Ceramic Particles in PLGA Matrix", Key Engineering Materials, Vols. 330-332, pp. 511-514, 2007

Online since:

February 2007




[1] Currey JD, Handbook of Composite (Elsevier Science Publishers BV 1983).

[2] Bonfield W et a. l: Biomater Vol. 2 (1981), p.185.

[3] Wang M et al.: Biomater Vol. 19 (1998), p.2357.

[4] Deng XM et a. l: Biomater Vol. 22 (2001), p.2867.

[5] Xueyu Q et al.: Biomacromolecules Vol. 6 (2005), p.1193.

[6] Shikinami Y et al.: Biomater Vol. 20 (1999), p.859.

[7] Li H et al.: Mater Lett. Vol. 57 (2003), p.2848.

[8] Fang LM et al.: Biomater Vol. 26 (2005), p.3471.