A Novel Way of Dispersing Fine Ceramic Particles in PLGA Matrix
α-tricalcium phosphate (α-TCP) was prepared by a wet precipitation reaction between calcium hydroxide and orthophosphoric acid solutions. The as-synthesised powder was then characterised using a Scanning Electron Microscope (SEM) equipped with Energy Dispersive Spectroscope (EDS), X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscope (FTIR). Analyses revealed that a phase-pure powder with a Ca/P ratio of 1.5 was produced. In addition, nanosized α-TCP particles of diameter ~ 70 nm were agglomerated to form larger particles of 10μm in diameter. It was found that by the combination of attritor milling and solution evaporation, the agglomerates of α-TCP nanoparticles could be broken down, and distributed evenly within the poly(D,L-lactic-co-glycolic acid) (PLGA) matrix. Thus, a α-TCP/PLGA nanocomposite was successfully produced by a modified solution evaporation method at room temperature followed by hot pressing at 150 °C. The achievable ceramic loading was approximately 38 wt.%, which was confirmed by thermal gravimetric analysis (TGA).
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Z. Yang et al., "A Novel Way of Dispersing Fine Ceramic Particles in PLGA Matrix", Key Engineering Materials, Vols. 330-332, pp. 511-514, 2007