Early Peri-Implant Osteogenesis with Functionally Graded Nanophase Hydroxyapatite/Bioglass Coating on Ti Alloys
Although compositional gradients could be manufactured for the functionally graded coating that was showed to improve bonding strength between the coating and the substrate, the biological efficacy of the graded coatings remained unclear. In this study, a functionally graded nanophase hydroxyapatite/bioglass (n-HA/bioglass) coating was prepared on a titanium (Ti) substrate for evaluating peri-implant osteogenesis in a canine model. The bone apposition and osteointegration of n-HA/bioglass coating were investigated at the interface compared with plasma spraying HA (PS-HA) coating. The results showed that the coating degraded gradually over time but not as fast as PS-HA coating did, and that more active bone apposition appeared on the n-HA/bioglass coating. The in vivo study indicated that an early osteogenesis and osteointegration at the interface could be stimulated by the use of n-HA/bioglass coating in biological environment.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Y. B. Tan et al., "Early Peri-Implant Osteogenesis with Functionally Graded Nanophase Hydroxyapatite/Bioglass Coating on Ti Alloys", Key Engineering Materials, Vols. 330-332, pp. 553-556, 2007