Bloodcompatibility Improvement of Titanium Oxide Film Modified by Hydrogen Plasma Reduction
In this work, nonstoicheometric titanium oxide film on silicon matrix was prepared by unbalanced reactive pulsed magnetron sputtering /hydrogen plasma reduction method. The film chemical composition was analyzed by X-ray diffraction and X-ray photoelectron spectroscopy (XPS). The XRD patterns of the prepared films showed that titanium oxide films possess the single phase rutile structure . the XPS spectra of the film displayed that the valence state of Ti is Ti4+, Ti3+ and Ti2+ respectively and the films were nonstoichiomeric Ti-O film. The evidence showed that isolated oxygen exist in films. Ti/O ratio of Ti-O film from the XPS data vary with depth under different reduction temperature and time. And it corresponded with platelet adhesion tests of Ti-O film in vitro. Antithrombotic property of reduced titanium oxide thin films was examined by platelet adhesion tests. The results showed that the Ti-O films with lower non-stoicheometrical extent posses the better anticoagulation property than stoichiomeric TiO2 film and the Ti-O films with higher non-stoicheometrical extent. Hence hydrogen introducing is an effective way to improve the bloodcompatibility of titanium oxide film.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Y. Xu et al., "Bloodcompatibility Improvement of Titanium Oxide Film Modified by Hydrogen Plasma Reduction", Key Engineering Materials, Vols. 330-332, pp. 557-560, 2007