FGF-2/Calcium Phosphate Composite Layer to Resist Bacterial Infection
A FGF-2-apatite composite layer (FGF-AP layer) was formed on the surface of Ti screws in a supersaturated calcium phosphate solution supplemented with FGF-2. By an in vitro study using fibroblastic NIH3T3 cells, it was confirmed that FGF-2 was immobilized in the layer without complete denaturation although the composite layer was formed at 37°C. When Ti screws with the FGF-AP layer were percutaneously implanted in the proximal tibial metaphysis of 16 rabbits, no osteomyelitis was observed in any rabbits although a FGF-2-free AP layer allowed osteomyelitis in some cases in our previous study. These results suggest that a FGF-AP layer formed on Ti screws is useful for resisting bacterial infection during external fixations.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Y. Sogo et al., "FGF-2/Calcium Phosphate Composite Layer to Resist Bacterial Infection", Key Engineering Materials, Vols. 330-332, pp. 691-694, 2007