Growth of Calcium Phosphate on Poled Piezoelectric Poly-L-lactic Acid Membrane by a Biomimetic Method


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The bioactivity of poled piezoelectric PLLA membrane was investigated by studying the calcium phosphate formation in vitro using a biomimetic method. Samples (φ10mm) were poled under DC electric field of 8~l0kV/cm at 70°C for 30 min followed by cooling under the electric field. Surface chemistry of the samples before and after poling treatment was studied by X-ray photoelectron spectroscopy (XPS). Poled/unpoled samples were immersed in supersaturated calcification solution (SCS) for periods up to 24 h (36.5°C). The surface morphology and composition of the soaked samples were evaluated by using scanning electron microscope (SEM) and X-ray diffraction analysis (XRD). Poled samples showed two different charged surfaces, negatively-charged surface (N-PLLA) and positively-charged surface (P-PLLA). On the N-PLLA surfaces, SEM together with XRD showed a gradually formed calcium phosphate (Ca-P), while no obvious Ca-P on either P-PLLA or unpoled samples was observed. This study demonstrated that poled piezoelectric PLLA substrates induce substantially higher level of Ca-P formation than electrically neutral substrates and only N-PLLA, however, can improve Ca-P formation after immersion in SCS.



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu






C. P. Huang et al., "Growth of Calcium Phosphate on Poled Piezoelectric Poly-L-lactic Acid Membrane by a Biomimetic Method", Key Engineering Materials, Vols. 330-332, pp. 703-706, 2007

Online since:

February 2007




[1] I. Yasuda: J. Kyoto Med. Soc. Vol. 4 (1953), p.395.

[2] M. Hartig, U. Joos and H.P. Wiesmann: Eur. Biophys. J. Vol. 29 (2000), p.499.

[3] J.Q. Feng, H.P. Yuan and X.D. Zhang: Biomaterials Vol. 18 (1997), p.1531.

[4] E. Fukada: Biorheology Vol. 32 (1995), p.593.

[5] Y. Matsusue, T. Yamamoto and S. Yoshii: J. Appl. Biomater. Vol. 2 (1991), p.1.

[6] F. Li, Q.L. Feng and F.Z. Cui: Surface And Coating Tech. Vol. 154 (2002), p.88.

[7] Q. Qiu, M. Sayer and M. Kawaja: J. Biomed. Mater. Res. Vol. 42 (1998), p.117.

[8] R.F. Valentini, T.G. Vargo and J.A. Gardella: Biomaterials Vol. 13 (1992), p.183.

[9] M. Vakiparta, A.P. Forsback and L.V. Lassila: J. Mater. Sci. Mater. In Med. Vol. 16 (2005), p.873.

[10] M. Ueshima, S. Nakamura and M. Ohgaki: Solid State Ionics Vol. 151 (2002), p.29.

[11] Y.J. Parka, K.S. Hwanga and J.E. Songa: Biomaterials Vol. 23 (2002), p.3859.

[12] K. Yamashita, N. Oikawa and T. Umegaki: Chem. Mater. Vol. 8 (1996), p.2697.

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