The purpose of this study was to determine if a strontium (Sr)-containing mixing liquid could be used as an exchanging agent for calcium phosphate cement crystallized with Sr-replacing hydroxyapatite (Sr-HAP). Alpha-tricalcium phosphate (α-TCP) powder was mixed with Srcontaining and phosphorous (P)-containing solutions, that is, SrCl2 or SrCl2+CaCl2 solution and NaH2PO4 or Na2HPO4 solution. After storage in the incubator for 7 days, the α-TCP crystals in all set cements were confirmed to have been transformed to HAP crystals by the mixing liquids. The XRD patterns of the set cements implied that the Sr-HAP could be precipitated by using Srcontaining solutions as the mixing liquid because of the chemical shift of a peak (002) in XRD of the HAP crystal. The solubility (shaking immersion in physiological saline) of set cements containing Sr was markedly higher than that of set cement not containing Sr. These results revealed that the Sr-containing solutions used as mixing liquids for α-TCP cement acted as precipitating agents for Sr-HAP. Sr-HAP-precipitating cement could be useful because of its pharmacological activity with high solubility.