An In Vivo Comparative Analysis of the Intra-Operative Properties of Injectable Calcium Phosphate/Calcium Sulphate Based Bone Cements

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The aim of this work was to assess the mixing, transfer and handling, properties, injectability, set time, wash-out characteristics, acceptance of hardware (i.e. stainless screws), and their delivery/transfer systems of self hardening synthetic bone cements made from calcium phosphate and calcium sulphate. Surgical procedures (i.e. cranioplasty) were performed on adult Labrador dogs using seven different bone cements from various manufacturers. Direct comparison of the defined intraoperative properties were evaluated and recorded. There is considerable variability with respect to application properties among commercially available injectable synthetic bone cements. Only one product was rated good to excellent in seven of the eight categories evaluated (6-excellent, 1-good, 1-fair) based on in-vivo tests. This study outlines the critical parameters required for successful implantation of cements that have to be understood when designing new injectable bone cements for the future.

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Periodical:

Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu

Pages:

799-802

Citation:

P. J. Catalano et al., "An In Vivo Comparative Analysis of the Intra-Operative Properties of Injectable Calcium Phosphate/Calcium Sulphate Based Bone Cements", Key Engineering Materials, Vols. 330-332, pp. 799-802, 2007

Online since:

February 2007

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$38.00

[1] Larsson, S., Bauer, T.W., The Use of Injectable Calcium Phosphate Cement for fracture fixation: A Review., Clinical Orthopaedics, No. 395, pp.23-32, (2002).

DOI: https://doi.org/10.1097/00003086-200202000-00004

[2] Chow, L.C., Constantino, P.D., Freidman, C.D., Self-Setting Calcium Phosphate Cements., Mat. Res. Soc. Symp. Vol 179, Materials Research Society, (1991).

[3] Robinson D, Alk D, Sandbank J, Farber R, Halperin N, Inflammatory reactions associated with a calcium sulphate bone substitute., Ann Transplant. 1999, 4(3-4), pp.91-7.

[4] Lee Gh, Khoury J G, Bell JE, Buckwalter JA Adverse reactions to Osteoset bone graft substitute the incidence in a consecutive series, Iowa Orthop J. 2002, 22: pp.35-8.

[5] Lewis KN, Puleo DA Mechanical degradation behaviour of polymer calcium sulfate composites, J. Mater Sci Mater Med. 2006 Jun; 17 (6), pp.531-7.

[6] Bohner M, Gbrueck U, Barralet J, Technological issues for the development of more efficient calcium phosphate bone cements: A critical assessment., Biomaterials 26 92005), pp.6423-6429.

DOI: https://doi.org/10.1016/j.biomaterials.2005.03.049