Acrylic bone cements are used to fix joint replacements to bone. The main substance in acrylic bone cement is biologically inert poly(methylmethacrylate), PMMA. The dense PMMA polymer structure of cement does not allow bone ingrowth into cement. Therefore, the main focus of our studies is to modify acrylic bone cement in order to improve its biological properties e.g., by creating porosity in the cement matrix. The porous structure is in situ created using pore-generating filler (i.e., 20 wt% of an experimental biodegradable polyamide) that is incorporated in acrylic bone cement. The aim of this in vitro study was to investigate the biomineralization of acrylic bone cement modified using an experimental biodegradable polyamide.