Control of Protein Initial Burst from Zinc-Hydroxyapatite / Poly(L-Lactide) System

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Control of protein release without the initial burst from zinc containing hydroxyapatite porous microparticles (Zn-HAp) was investigated with a novel formulation method. The formulation method was a coat of polyL(L-lactide; PLA) on the microparticle with nano-thickness, which obviously suppressed the initial burst of protein release compared with the microparticles without the formulation, the coat of PLA. The HAp/PLA microparticle with 1-20μm of the size distribution was available for the drug delivery carrier of proteins without the degradation.

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Periodical:

Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu

Pages:

857-860

Citation:

T. Tonegawa et al., "Control of Protein Initial Burst from Zinc-Hydroxyapatite / Poly(L-Lactide) System", Key Engineering Materials, Vols. 330-332, pp. 857-860, 2007

Online since:

February 2007

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$38.00

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