Control of Protein Initial Burst from Zinc-Hydroxyapatite / Poly(L-Lactide) System
Control of protein release without the initial burst from zinc containing hydroxyapatite porous microparticles (Zn-HAp) was investigated with a novel formulation method. The formulation method was a coat of polyL(L-lactide; PLA) on the microparticle with nano-thickness, which obviously suppressed the initial burst of protein release compared with the microparticles without the formulation, the coat of PLA. The HAp/PLA microparticle with 1-20μm of the size distribution was available for the drug delivery carrier of proteins without the degradation.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
T. Tonegawa et al., "Control of Protein Initial Burst from Zinc-Hydroxyapatite / Poly(L-Lactide) System", Key Engineering Materials, Vols. 330-332, pp. 857-860, 2007