Effect of Mn on Protein Adsorption on Mn-TCP/FHA Coatings


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The effect of Mn on the protein adsorption of calcium phosphate coatings is investigated in this work. Mn containing β-tricalcium phosphate (Mn-TCP) is first prepared through a coprecipitation based methods. Then Mn-TCP is dispersed into the fluoridated hydroxyapatite (FHA) precursor sol. Mn-TCP/FHA biphasic coatings are prepared with these sols. After cell culture, it is found the amount of protein adsorbed on the coatings following this rule: Mn-TCP/FHA > β-TCP/FHA > FHA. That is ascribed to two reasons: a) Ca and PO4 releasing can promote the activity of cells; b) Mn releasing promotes protein activation even at quite low concentration.



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




K. Cheng, "Effect of Mn on Protein Adsorption on Mn-TCP/FHA Coatings", Key Engineering Materials, Vols. 330-332, pp. 881-884, 2007

Online since:

February 2007





[1] K. De Groot, R. Geesink, C.P.A.T. Klein and P. Serekian: J. Biomed. Mater. Res. Vol. 21 (1987), p.1375.

[2] J.E. Ellingsen and S.P. Lyngstadaas: Bio-implant Interface: Improving Biomaterials and Tissue Reactions, (CRC press, Boca Raton 2003).

DOI: https://doi.org/10.1201/9780203491430

[3] M. Kanatani, T. Sugimoto, M. Fukase and T. Fujita: Biochem Biophys Res Commun. Vol. 181(3) (1991), p.1425.

[4] S. Overgaard, M. Lind, K. Josephsen, A.B. Maunsbach, C. Bnger and K. Soballe: J. Biomed. Mater. Res. Vol. 39 (1998), p.141.

[5] K. Cheng, S. Zhang and W. Weng: Thin Solid Films (2006), in press.

[6] Y. Sogo, T. Sakurai, K. Onuma and A. Ito: J. Biomed. Mater. Res. Vol. 62 (2002), p.457.

[7] C.W. Bock, A.K. Katz, G.D. Markham and J.P. Glusker: Journal of Americam Chemical Society Vol. 121 (1999), p.7360.

[8] T.V. Byzova, W. Kim, R.J. Midura and E.F. Plow: Experimental Cell Research Vol. 254 (2000), p.299.

[9] C. Zhou, W.J. Weng, X.L. Deng, K. Cheng, X.G. Liu, P.Y. Du, G. Shen and G.R. Han: Biomaterials Vol. 26 (2005), p.5276.