Effect of Mn on Protein Adsorption on Mn-TCP/FHA Coatings
The effect of Mn on the protein adsorption of calcium phosphate coatings is investigated in this work. Mn containing β-tricalcium phosphate (Mn-TCP) is first prepared through a coprecipitation based methods. Then Mn-TCP is dispersed into the fluoridated hydroxyapatite (FHA) precursor sol. Mn-TCP/FHA biphasic coatings are prepared with these sols. After cell culture, it is found the amount of protein adsorbed on the coatings following this rule: Mn-TCP/FHA > β-TCP/FHA > FHA. That is ascribed to two reasons: a) Ca and PO4 releasing can promote the activity of cells; b) Mn releasing promotes protein activation even at quite low concentration.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
K. Cheng, "Effect of Mn on Protein Adsorption on Mn-TCP/FHA Coatings", Key Engineering Materials, Vols. 330-332, pp. 881-884, 2007