Novel Micro-CT Based 3-Dimentional Structural Analyses of Porous Biomaterials


Article Preview

A porous structure comprises pores and pore throats with a complex three-dimensional network structure, and many investigators have described the relationship between average pore size and the amount of bone ingrowth. However, the influence of network structure or pore throats for tissue ingrowth has rarely been discussed. Bioactive porous titanium implants with 48% porosity were analyzed using specific algorithms for three-dimensional analysis of interconnectivity based on a micro focus X-ray computed tomography system. In vivo histological analysis was performed using the very same implants implanted into the femoral condyles of male rabbits for 6 weeks. This matching study revealed that more poorly differentiated pores tended to have narrow pore throats, especially in their shorter routes to the outside. Data obtained suggest that this sort of novel analysis is useful for evaluating bone and tissue ingrowth into porous biomaterials.



Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu




B. Otsuki et al., "Novel Micro-CT Based 3-Dimentional Structural Analyses of Porous Biomaterials", Key Engineering Materials, Vols. 330-332, pp. 967-970, 2007

Online since:

February 2007




[1] Hollister SJ. : Nat Mater Vol. 4(7) (2005), p.518.

[2] Kuboki Y, Takita H, Kobayashi D, Tsuruga E, Inoue M, Murata M, et al. : J Biomed Mater Res 1998 Vol. 39(2), p.190.

[3] Hulbert SF, Young FA, Mathews RS, Klawitter JJ, Talbert CD, Stelling FH. : J Biomed Mater Res Vol. 4(3) (1970), p.433.

[4] Holy CE, Fialkov JA, Davies JE, Shoichet MS. : J Biomed Mater Res A Vol. 65(4) (2003), p.447.

[5] Itala AI, Ylanen HO, Ekholm C, Karlsson KH, Aro HT. : J Biomed Mater Res Vol. 58(6) (2001), p.679.

[6] Takemoto M, Fujibayashi S, Otsuki B, Matsushita T, Kokubo T, Nakamura T. : Bioceramics, Vol 18 (2006), p.1095.

[7] Wen CE, Mabuchi M, Yamada Y, Shimojima K, Chino Y, Asahina T. : Scripta Materialia, Vol 45(2001), p.1147.


[8] Fujibayashi S, Neo M, Kim HM, Kokubo T, Nakamura T. : Biomaterials Vol. 25(3) (2004), p.443.

[9] Takemoto M, Fujibayashi S, Neo M, Suzuki J, Kokubo T, Nakamura T. : Biomaterials Vol. 26(30) (2005), p.6014.

[10] Otsu N. : IEEE Trans Syst Man Cybern 1979 1979/1; SMC-9(1): p.62.

[11] Lin CL, Miller JD. : Chem Eng Sci Vol. 77 (2000), p.79.

[12] Moore MJ, Jabbari E, Ritman EL, Lu L, Currier BL, Windebank AJ, et al. : J Biomed Mater Res A Vol. 71(2) (2004), p.258.

[13] Pabbruwe MB, Standard OC, Sorrell CC, Howlett CR. : Biomaterials Vol. 25(20) (2004), p.4901.