Biocompatibility of Near-IR Sensitive Au-Based Nanoparticles as the Potential Drug Delivery Carriers

Abstract:

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We successfully synthesized near infrared (NIR) sensitive Au(shell)-Au2S(core) nanoparticles, where Au2S dielectric core was encapsulated by a thin gold shell. The cytotoxicity in vitro and biodistribution in vivo of Au-Au2S nanoparticles was studied by using NIH3T3 cells and KM mice, respectively. The quantitative analysis of Au in each tissue of mice was done by using the Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Au-Au2S nanoparticles (< 300 μg/ml) showed good biocompatibility. Au-Au2S nanoparticles were preferentially taken up by the liver and spleen, and ultimately eliminated mostly in the feces.

Info:

Periodical:

Key Engineering Materials (Volumes 334-335)

Edited by:

J.K. Kim, D.Z. Wo, L.M. Zhou, H.T. Huang, K.T. Lau and M. Wang

Pages:

1177-1180

DOI:

10.4028/www.scientific.net/KEM.334-335.1177

Citation:

B. Zhang et al., "Biocompatibility of Near-IR Sensitive Au-Based Nanoparticles as the Potential Drug Delivery Carriers", Key Engineering Materials, Vols. 334-335, pp. 1177-1180, 2007

Online since:

March 2007

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Price:

$35.00

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