Fabrication and Characterization of Composite Microspheres Containing Carbonated Hydroxyapatite Nanoparticles

Abstract:

Article Preview

Nano-sized carbonated hydroxyapatite (CHAp) particles were firstly synthesized using a nanoemulsion method. TEM analyses revealed that as-synthesized nanoparticles were calcium-deficient and spherical in shape (diameter: 16.8±2.6nm). Biocomposite microspheres comprising CHAp nanoparticles and poly(L-lactide) (PLLA) were fabricated using the single emulsion solvent evaporation technique. SEM images showed that composite microspheres were mainly 5-30 μm in size despite the change of CHAp nanoparticle content. When the CHAp nanoparticle content in composite microspheres was below 10 wt%, all nanoparticles were encapsulated within the microspheres which possessed a nanocomposite structure. DSC results showed that the crystallinity of the PLLA matrix of microspheres increased from 38 to 42% when the CHAp nanoparticle content was increased from 0 to 20 wt%. The biocomposite microspheres should be a suitable material for constructing bone tissue engineering scaffolds.

Info:

Periodical:

Key Engineering Materials (Volumes 334-335)

Edited by:

J.K. Kim, D.Z. Wo, L.M. Zhou, H.T. Huang, K.T. Lau and M. Wang

Pages:

1221-1224

DOI:

10.4028/www.scientific.net/KEM.334-335.1221

Citation:

W. Y. Zhou et al., "Fabrication and Characterization of Composite Microspheres Containing Carbonated Hydroxyapatite Nanoparticles", Key Engineering Materials, Vols. 334-335, pp. 1221-1224, 2007

Online since:

March 2007

Export:

Price:

$35.00

In order to see related information, you need to Login.

In order to see related information, you need to Login.