Hydroxyapatite Nano-Particles Coating on the Pore Surface Within Poly(DL-lactic-co-glycolic acid) Scaffold
This paper describes a novel method for coating hydroxyapatite (HA, Ca10(PO4)6(OH)2) nano-particles onto poly(DL-lactic-co-glycolic acid) (PLGA) scaffold. Paraffin micro-spheres were used as porogens to create porous scaffolds and as vehicles to transfer HA into PLGA scaffold. HA nano-particles / 50% ethanol suspension was mixed with paraffin micro-spheres. The paraffin micro-spheres / HA suspension were pressed together to form a paraffin scaffold. After it was dried, the HA was coated on the surface of the paraffin spheres. Then, PLGA solution was cast into the inter space among the paraffin micro-spheres and then the solvent was evaporated. Afterwards, the paraffin micro-spheres were dissolved and removed. PLGA scaffolds with controlled pore size, good interconnectivity and high porosity were obtained. The HA nano-particles were transferred from the paraffin surface to the surface of the pore wall throughout the PLGA scaffold.
J.K. Kim, D.Z. Wo, L.M. Zhou, H.T. Huang, K.T. Lau and M. Wang
J. S. Li and A. F.T. Mak, "Hydroxyapatite Nano-Particles Coating on the Pore Surface Within Poly(DL-lactic-co-glycolic acid) Scaffold", Key Engineering Materials, Vols. 334-335, pp. 1237-1240, 2007