Compressive experiments and finite element method (FEM) have been used to study the mechanical behavior of composite laminate with plies drop-off. A user subroutine has been implemented to ABAQUS to simulate the damage development of the laminate plate. This user subroutine has taken consideration of the mechanical properties degradation according to development of three types of damage. The load-strain curves can agree with each other between experiments and FEM. The detail of damage development of the plies drop-off composite laminate under compressive loading can be described as followed. Matrix cracking damage and fiber-matrix shearing damage occur simultaneously at first, and then fiber buckling damage initiates. Matrix cracking and fiber-matrix shearing are very dangerous to the carrying capacity of laminate and fiber buckling intensifies further this effect. The initiation and development of fiber buckling indicates that laminate loses carrying capacity at all.