Bone repair method has run to a new stage of bone tissue engineering. Doctors use bone scaffold to fill bone trauma and expect human regeneration ability to reconstruct bone trauma while bone is degrading. Scaffold is essential to bone tissue engineering. Scaffold should introduce new bone with scaffold’s conduction channel. But it’s still very difficult for scaffold to mimic fine structure of bone. Ideal scaffold should have similar component and microstructure to natural bone, which makes it more biocompatible and better to reconstructed bone. So we forward microCT aided design and preparation to solve this problem. MicroCT outputs both shape and three-dimensional internal density information. Then, we build computer model of scaffold with acquired microstructure. We fabricate scaffold that mimics natural bone by 3D rapid prototype machine.