Bone Formation in Non-Osseous Tissues of Biphasic HA/β-TCP Bioceramics Sintered by Different Ways
In order to improve the bioactivity of calcium phosphate bioceramics, biphasic HA/β-TCP (BCP) bioceramics were prepared by the microwave sintering and the microwave plasma sintering. Bone-like apatite formation of the resulting samples was investigated in simulated body fluid (SBF). The samples were also implanted in dorsal muscles of healthy dogs for 1.5and 3 months. All samples after taking out were examined by histological observation. Bone formation in different sintering ways and temperatures was investigated in details. Better osteoinductivity was found in samples sintered by the microwave and microwave plasma instead of the conventional furnace, as well as by lower temperature (1050 oC) instead of higher temperature (1150 oC). It accounts for that the increase in degradability of materials sintered by microwave and microwave plasma or lower temperature leads to the better of bone-like apatite formation and bone formation due to fine grains and lower crystallinity.
Wei Pan and Jianghong Gong
J. G. Ran et al., "Bone Formation in Non-Osseous Tissues of Biphasic HA/β-TCP Bioceramics Sintered by Different Ways", Key Engineering Materials, Vols. 336-338, pp. 1666-1669, 2007