20wt% bioactive glass was added to the pure titanium power by means of subsonic flame spraying. Soak test in vitro was performed with the sprayed samples after heat treatment, and the polarization curve was determined. The result shows that pH of the solution varied during the 60 h immersion of the coating in the simulated body fluid. This related to the fact that TiO2.CaTi4O9.NaTiO2 etc were dissolved and precipitated in the coating. With different immersion time, the coating weight increased first, and then decreased. The self-corrosion potential and morphology of the coating were influenced by different polarization corrosion rate. When the polarization corrosion rate was low, it contributed to the growth of bone-like apatite, and then the corrosion was restrained. In simulated body fluid, absorption, dissolution, and the formation and growth of new phases took place in the coating. Bone-like apatite may form on the coating surface, which indicates the excellent biocompatibility of 8Ti2G bio-composite coating.