Transparent bulk CdSe/SiO2 nanocomposites, containing semiconductor CdSe nanocrystals well dispersed in silica glass matrix, were obtained by using sol-gel method and in-situ growth technique. The nanocomposites were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), UV-VIS absorption spectra and X-ray Photoelectron Spectroscopy (XPS). X-ray diffraction and transmission electron microscope measurements confirmed a cubic crystallographic structure of the nanoparticles, with mean diameter smaller than 10 nm. UV-VIS absorption spectra displayed a marked blue shift of the absorption band edge that was attributed to quantum confinement effects. XPS together with XRD proved that silica matrix plays an important role in enhancing the NCs’ stability.