Study on Silk I Porous 3-D Scaffolds


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A series of porous silk fibroin materials were prepared by freezing fibroin aqueous solution at –18 °C for 10 days. The process required no freeze-drying, chemical cross-linking, or the aid of other polymeric materials. X-ray powder diffraction patterns from the porous silk materials displayed features of crystal of metastable silk I polymorph. By adjusting the preparation conditions, silk I porous materials with average pore diameter of 30-240 μm and porosity of 70 -95 % can be prepared. The silk I porous materials were embedded in hypodermis on the dorsal surface of SD white rats, resulting that all rats survived with good general condition, and silk I porous materials were degraded and absorbed mostly in 6 weeks.



Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon




S. Z. Lu et al., "Study on Silk I Porous 3-D Scaffolds", Key Engineering Materials, Vols. 342-343, pp. 233-236, 2007

Online since:

July 2007




[1] W Halsted: Ann Surg Vol. 16(1892), p.505.

[2] O Kratky, E Schauenstein, A Sekora: Nature Vol. 165(1950), p.319.

[3] G. H. Altman, Frank Diaz, Caroline Jakuba, Tara Calabro, R.L. Horan, J.S. Chen, Helen Lu, J. Richmond, D. L. Kaplan: Biomaterials Vol. 24 (2003), p.401.


[4] R. Nazarov, H. J. Jin, D. L. Kaplan: Biomacromolecules 5(2004), p.718.

[5] U. J. Kim, J. Park, H. J. Kim, M. Wada, D. L. Kaplan: Biomaterials Vol. 26(2005), p.2775.

[6] MZ Li, ZY Wu, CS Zhang, SZ Lu, HJ Yan, D. Huang, HJ Ye: J Appl Polym Sci Vol. 79 (2001), p.2192.

[7] K. Hirabayashi, H. Ishikava: Sen-i Gakkaishi Vol. 23(1967), p.538.

[8] M. Shimizu: Sanshi Shikenjo Houkoku Vol. 10(1941), p.475.

[9] R. E. Marsh, R. B. Corey, L. Pauling: Biochim. Biophys. Acta Vol. 16(1955), p.1.

[10] MZ Li, SZ Lu, ZY Wu, HJ Yan, JY Mo, LH Wang: J Appl Polym Sci Vol. 79, (2001), p.2185.