Genotoxic Potential of Regenerated Silk Fibroin Films by Different Cross-Linking Mode

Abstract:

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Emerging studies have showed that silk fibroin might be as a naturally occurring degradable biomaterial for tissue engineering with unique mechanical properties, biocompatib ility and processability. To optimize the formation of the regenerated silk fibroin film, in thi s study, we examined the genotoxic potential of the regenerated silk fibroin films by differe nt cross-linking mode with micronucleus and the single cell gel electrophoresis (comet) assa y. The data showed that MNF in group PC and group SD showed significantly no differenc e with blank group (P>0.05), and no evident comet tails were observed. However, the resul t of EC group was significantly different from the control group(P<0.01). Taken together, R SFFs in group PC and group SD have no evident genotoxicity, which is better than group EC.

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon

Pages:

257-260

DOI:

10.4028/www.scientific.net/KEM.342-343.257

Citation:

J. C. Miao et al., "Genotoxic Potential of Regenerated Silk Fibroin Films by Different Cross-Linking Mode", Key Engineering Materials, Vols. 342-343, pp. 257-260, 2007

Online since:

July 2007

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Price:

$35.00

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