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Genotoxic Potential of Regenerated Silk Fibroin Films by Different Cross-Linking Mode
Abstract:
Emerging studies have showed that silk fibroin might be as a naturally occurring degradable biomaterial for tissue engineering with unique mechanical properties, biocompatib ility and processability. To optimize the formation of the regenerated silk fibroin film, in thi s study, we examined the genotoxic potential of the regenerated silk fibroin films by differe nt cross-linking mode with micronucleus and the single cell gel electrophoresis (comet) assa y. The data showed that MNF in group PC and group SD showed significantly no differenc e with blank group (P>0.05), and no evident comet tails were observed. However, the resul t of EC group was significantly different from the control group(P<0.01). Taken together, R SFFs in group PC and group SD have no evident genotoxicity, which is better than group EC.
Info:
Periodical:
Main Theme:
Edited by:
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages:
257-260
DOI:
10.4028/www.scientific.net/KEM.342-343.257
Citation:
J. C. Miao et al., "Genotoxic Potential of Regenerated Silk Fibroin Films by Different Cross-Linking Mode", Key Engineering Materials, Vols. 342-343, pp. 257-260, 2007
Online since:
July 2007
Authors:
Price:
$35.00
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