In Vitro Studies of Macrophage Biological Behavior on Cardiovascular Biomaterials


Article Preview

Macrophages play a critical role in inflammatory response to implanted biomaterials and formation of restenosis. Macrophage adhesion may lead to macrophage activation and smooth muscle cell proliferation. Titanium oxide films on stainless steel are potential biomaterials for application to vascular stents. They have different influences on smooth muscle cell proliferation in in vivo tests, which could be the main reason for restenosis, but the mechanism is not clear. In this study we show that titanium oxide films can reduce inflammatory reaction with macrophages. Unstimulated macrophages release small amounts of chemical substance such as NO and give slight effect on smooth muscle cell proliferation.



Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon




A. S. Zhao et al., "In Vitro Studies of Macrophage Biological Behavior on Cardiovascular Biomaterials", Key Engineering Materials, Vols. 342-343, pp. 309-312, 2007

Online since:

July 2007




[1] A. Colombo, G. Sangiorgi: J. Am. Coll. Cardiol. Vol. 43(2004), p.24.

[2] P. Thomsen, Ch. Gretzer: Current Opinion in Solid State and Materials Science, Vol. 5 (2001) , p.163.

[3] M. ch. Shen, Th. A Horbett: J Biomed Mater Res Vol 57(2001), p.336.

[4] M. D. Josef Niebauer, P. Severin, M. D. Schwarzacher: Circulation Vol. 100(1999), p.1830.

[5] S. A. Ahmed, Jr. RM. Gogal, J. E. and Walsh: J Immunol Methods, Vol. 170(1994) , pp.211-24.

[6] P. faller MA, Q. Vu, and M. Lancaster : J Clin Microbiol, Vol. 32 (1994), pp.1625-1628.

[7] F. G. P. Welt, C. Rogers: Arterioscler Thromb Vasc Biol Vol. 22(2002), p.1769.

[8] A Beuernfeind: An Age Chem Vol. 41(1997), p. (2041).

Fetching data from Crossref.
This may take some time to load.