Characterization of the Gel-Spun Tubular Scaffold for Cardiovascular Tissue Engineering


Article Preview

A tubular and fibrous scaffold was fabricated from an elastic polymer, poly (L-lactideco- ε-caprolactone) (PLCL; Mn 193,813, Mw 538,623) 50:50 by using a novel gel spinning apparatus. To characterize the gel-spun scaffold, we investigated morphology, tensile property, tissue in-growth rate and degradation rate. From SEM images, fibrous structure in the scaffold wasn’t fabricated well in the condition of 4% gel concentration. In general, the thickness level of microfibers increased as the gel concentration increased. In addition, the gel-spun scaffolds showed stronger tensile properties in the circumferential direction than the longitudinal direction. 5%, 7.5%, 10% and 12.5% scaffolds were analyzed in both directions: circumferential direction and longitudinal direction. On the other hand, the gel-spun scaffolds have been implanted in mouse to examine the degradation rate in vivo and tissue in-growth aspects, compared to extruded scaffolds. Both shows very similar degradation rates, but the aspect in tissue in-growth was different. In conclusion, gel-spun PLCL scaffolds have good characteristics as a plausible scaffold for cardiovascular tissue engineering.



Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon




E. N. Chung et al., "Characterization of the Gel-Spun Tubular Scaffold for Cardiovascular Tissue Engineering", Key Engineering Materials, Vols. 342-343, pp. 321-324, 2007

Online since:

July 2007




[1] S. W. Cho, H. J. Park, J. H. Ryu, S. H. Kim, Y. H. Kim, C.Y. Choi, M. J. Lee, J. S. Kim, I. S. Jang, D.I. Kim and B. S. Kim: Biomaterials, Vol. 26, (2005), p. (1915).


[2] M. R. Hoenig, G. R. Campbel, B. E. Rolfe and J. H. Campbell: Arterioscler. Thromb. Vasc. Biol., Vol. 25, (2005), p.1128.

[3] S. I. Jeong, B. S. Kim, Y. M. Lee, K. J. Ihn, S. H. Kim and Y. H. Kim, Biomacromolecules, Vol. 5, (2004), p.1303.

[4] S. H. Kim, S. H. Kim and Y. H. KIM: Tissue Engineering and Regenerative Medicine, Vol. 3(1), (2006), p.13.