The Effects of Collagen Membrane Coated with PLGA on Bone Regeneration in Rat Calvarial Defects

Abstract:

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The purpose of this study was to evaluate the effects of collagen membrane coated with PLGA on bone regeneration in rat calvarial defect. Five groups of 10 animals each received either collagen membrane coated with 0.5%, 1%, 3% concentration of PLGA, collagen membrane only or surgical control. Each group of animals was healed into 2 healing periods of 2(5 animals) and 8(5 animals)weeks and histologic and histomorphometric analysis were done. The results of the following study revealed that surgical implantation of collagen membranes coated with PLGA enhanced local bone formation at both 2 and 8 weeks independent of different PLGA concentrations. In conclusion, collagen membrane coated with PLGA shows a significant bone formation behavior irrespective of their concentration.

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon

Pages:

357-360

DOI:

10.4028/www.scientific.net/KEM.342-343.357

Citation:

K. Y. Song et al., "The Effects of Collagen Membrane Coated with PLGA on Bone Regeneration in Rat Calvarial Defects ", Key Engineering Materials, Vols. 342-343, pp. 357-360, 2007

Online since:

July 2007

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Price:

$35.00

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