The Effects of Calcium Phosphate-Chitosan Block Bone Graft on the Periodontal Regeneration in One Wall Intrabony Defects in Beagle Dogs
This study evaluated periodontal repair and biomaterial reaction following implantation of a newly fabricated calcium phosphate chitosan block bone and chitosan membrane on the regeneration of 1- wall intrabony defects in the beagle dogs. The surgical control group received a flap operation only, while experimental group was treated with calcium phosphate chitosan block bone and/or chitosan membrane. All dogs were uneventful healing without any complication. The subjects were sacrificed 8 weeks after the experimental surgery, and a comparative histological and histometric examination was done. Chitosan membrane group significantly enhanced bone regeneration compared to control, CaP-chitosan block bone and combination group. Chitosan membrane remnants were observed in chitosan and combination group, while CaP-chitosan bone materials were resorbed completely. These results suggest that Chitosan membrnae significantly enhanced bone and cementum formation in advanced periodontal defects.
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
S. K. Kim et al., "The Effects of Calcium Phosphate-Chitosan Block Bone Graft on the Periodontal Regeneration in One Wall Intrabony Defects in Beagle Dogs ", Key Engineering Materials, Vols. 342-343, pp. 393-396, 2007